1,213 research outputs found
Exploring Information Technologies to Support Shotgun Proteomics
Shotgun proteomics refers to the direct analysis of complex protein mixtures to create a profile of the proteins present in the cell. These profiles can be used to study the underlying biological basis for cancer development. Closely studying the profiles as the cancer proliferates reveals the molecular interactions in the cell. They provide clues to researchers on potential drug targets to treat the disease. A little more than a decade old, shotgun proteomics is a relatively new form of discovery, one that is data intensive and requires complex data analysis. Early studies indicated a gap between the ability to analyze biological samples with a mass spectrometer and the information systems available to process and analyze this data. This thesis reflects on an automated proteomic information system at the University of Colorado Central Analytical Facility. Investigators there are using cutting edge proteomic techniques to analyze melanoma cell lines responsible for skin cancer in patients. The paper will provide insight on key design processes in the development of an Oracle relational database and automation system to support high-throughput shotgun proteomics in the facility. It will also discuss significant contributions, technologies, software, a data standard, and leaders in the field developing solutions and products in proteomics
Infrared spectroscopy of NGC 1068: Probing the obscured ionizing AGN continuum
The ISO-SWS 2.5-45 um infrared spectroscopic observations of the nucleus of
the Seyfert 2 galaxy NGC 1068 (see companion paper) are combined with a
compilation of UV to IR narrow emission line data to determine the spectral
energy distribution (SED) of the obscured extreme-UV continuum that
photoionizes the narrow line emitting gas in the active galactic nucleus. We
search a large grid of gas cloud models and SEDs for the combination that best
reproduces the observed line fluxes and NLR geometry. Our best fit model
reproduces the observed line fluxes to better than a factor of 2 on average and
is in general agreement with the observed NLR geometry. It has two gas
components that are consistent with a clumpy distribution of dense outflowing
gas in the center and a more extended distribution of less dense and more
clumpy gas farther out that has no net outflow. The best fit SED has a deep
trough at ~4 Ryd, which is consistent with an intrinsic Big Blue Bump that is
partially absorbed by ~6x10^19 cm^-2 of neutral hydrogen interior to the NLR.Comment: 15 pp, 4 figures, ApJ accepte
Diagnostico situacional sobre la fecundidad como problema de salud pública
Graficas, tablas, encuestaLa planificación familiar es un derecho que tiene todo hombre y toda mujer a decidir voluntariamente en qué momento y cuántos hijos desean y puedan tener. Toda pareja debe definir cuándo, cómo y con qué planificar el nacimiento de sus hijos puesto que son ellos responsables de velar por su bienestar.
Estos planes no solo ayudan a prevenir embarazos no deseados, sino también a proteger la salud de las mujeres, espaciar el nacimiento de sus hijos, evitar abortos clandestinos así como infecciones de transmisión sexual como el VIH.
La planificación familiar contribuye a mejorar la calidad de vida de los seres humanos, evitando embarazos no deseados, permitiendo a las parejas programar su descendencia. Los jóvenes pueden dedicar su tiempo y su esfuerzo a su capacitación y aprendizaje. Los padres con menor número de hijos tienen una mejor capacidad de proveer alimento, ropa, salud, vivienda y educación a sus niños. Los métodos de planificación familiar protegen la vida de la mujer con alto riesgo materno. Hacia el futuro solo la planificación familiar, podrá garantizar la supervivencia de la humanidad, ya que ante recursos naturales escasos como el agua y los suelos fértiles, el crecimiento demográfico no controlado disminuye la oportunidad de vida en el planeta.No Abstrac
J/psi suppression at forward rapidity in Au+Au collisions at sqrt(s_NN)=39 and 62.4 GeV
We present measurements of the J/psi invariant yields in sqrt(s_NN)=39 and
62.4 GeV Au+Au collisions at forward rapidity (1.2<|y|<2.2). Invariant yields
are presented as a function of both collision centrality and transverse
momentum. Nuclear modifications are obtained for central relative to peripheral
Au+Au collisions (R_CP) and for various centrality selections in Au+Au relative
to scaled p+p cross sections obtained from other measurements (R_AA). The
observed suppression patterns at 39 and 62.4 GeV are quite similar to those
previously measured at 200 GeV. This similar suppression presents a challenge
to theoretical models that contain various competing mechanisms with different
energy dependencies, some of which cause suppression and others enhancement.Comment: 365 authors, 10 pages, 11 figures, 4 tables. Submitted to Phys. Rev.
C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are (or will be) publicly available at
http://www.phenix.bnl.gov/papers.htm
Search for Top Squark Pair Production in the Dielectron Channel
This report describes the first search for top squark pair production in the
channel stop_1 stopbar_1 -> b bbar chargino_1 chargino_1 -> ee+jets+MEt using
74.9 +- 8.9 pb^-1 of data collected using the D0 detector. A 95% confidence
level upper limit on sigma*B is presented. The limit is above the theoretical
expectation for sigma*B for this process, but does show the sensitivity of the
current D0 data set to a particular topology for new physics.Comment: Five pages, including three figures, submitted to PRD Brief Report
Cross Section and Transverse Single-Spin Asymmetry of Mesons in Collisions at GeV at Forward Rapidity
We present a measurement of the cross section and transverse single-spin
asymmetry () for mesons at large pseudorapidity from
~GeV collisions. The measured cross section for
~GeV/ and is well described by a
next-to-leading-order perturbative-quantum-chromodynamics calculation. The
asymmetries have been measured as a function of Feynman- () from
, as well as transverse momentum () from
~GeV/. The asymmetry averaged over positive is
. The results are consistent with prior
transverse single-spin measurements of forward and mesons at
various energies in overlapping ranges. Comparison of different particle
species can help to determine the origin of the large observed asymmetries in
collisions.Comment: 484 authors, 13 pages, 11 figures, 4 tables, 2008 data. v2 is version
accepted by Phys. Rev. D. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be)publicly
available at http://www.phenix.bnl.gov/papers.htm
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